Bone Mineral Changes in Epilepsy Patients During Initial Years of Antiepileptic Drug Therapy

B Shiek Ahmad; TJ O'Brien; A Gorelik; KD Hill; JD Wark

Journal article

Bone Mineral Changes in Epilepsy Patients During Initial Years of Antiepileptic Drug Therapy

B Shiek Ahmad, TJ O'Brien, A Gorelik, KD Hill, JD Wark

Journal of Clinical Densitometry | ELSEVIER SCIENCE INC | Published : 2016

DOI: 10.1016/j.jocd.2016.07.008

Abstract

Antiepileptic drug (AED) therapy is associated with decreased bone mineral density; however, the time course for this development is unclear. The aim of this study was to evaluate bone mineral changes during the initial years of AED therapy in AED-naive, newly diagnosed epilepsy patients compared with non-AED users. In 49 epilepsy patients newly started on AEDs and in 53 non-AED users of both genders, bone mineral density (BMD) and bone mineral content were measured using dual-energy X-ray absorptiometry at baseline (within the first year of therapy) and at least 1 yr later. Bone changes between the 2 assessments, adjusted for age, height, and weight, were calculated as the annual rate of ch..

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University of Melbourne Researchers

Mrs Alex Gorelik Author

Prof John Wark Author

Related Projects (1)

The effect of antiepileptic medication on indices of bone health and risk factors for falls and fractures

Epilepsy is a common brain disorder and most patients with epilepsy take anti-epileptic drugs (AEDs) for many years. These patients have hig..

Grants

Awarded by Novartis

Funding Acknowledgements

The Department of Medicine, University of Melbourne and in part NHMRC Project Grant (ID No: 400089) financially supported this research. Professors Wark and O'Brien received financial support from UCB Pharma and Novartis for unrelated research. Dr Shiek Ahmad was supported by a PhD scholarship from the University of Malaya and the Malaysian Ministry of Higher Education. Professor Hill and Ms Gorelik report no disclosures.